研究领域属于物理、化学、生物、计算机科学的交叉领域。我们使用传统及先进的分子建模与模拟方法研究生物过程及生物体系的有趣物理问题,研究兴趣包括:蛋白质变构效应、阿尔兹海默症相关的beta-淀粉样多肽的低聚体结构及其与白蛋白的相互作用机制、多肽纳米材料。 文章列表: 1. Y. Gao, G. Guo, J. Watzlawik, P. S. Randolph, E. J. Lee, D. Huang, S. M. Stagg, H.-X. Zhou, T. L. Rosenberry, A. K. Paravastu. Out-of-register parallel b-sheets and antiparallel b-sheets coexist in 150-kDa oligomers formed by amyloid-b(1-42), J. Mol. Biol. 2020, 432(16): 4388-4407. 2. C. Guo and H.-X. Zhou. Fatty acids compete with Ab in binding to serum albumin by quenching its conformational flexibility, Biophys. J. 2019, 116(2): 248-257. 3. C. Guo and H.-X. Zhou. Unidirectional allostery in the regulatory subunit RIa facilitates efficient deactivation of protein kinase A. Proc. Natl. Acad. Sci. U. S. A. 2016, 113: E6776-E6785. 4. C. Guo, ZA Amon, R. Qi, Q. Zhang, L. Adler-Abramovich, E. Gazit and G. Wei. Expanding the nanoarchitectural diversity through aromatic di- and tri-peptide coassembly: nanostructures and molecular mechanisms. ACS Nano 2016, 10 (9):8316-8324. 5. Y. Sun, Z. Qian, C. Guo and G. Wei. Amphiphilic peptides A6K and V6K display distinct oligomeric structures and self-assembly dynamics: a combined all-atom and coarse-grained simulation study. Biomacromolecules 2015, 16 (9): 2940-2949. 6. C. Guo, S. Cote, N. Mousseau and G. Wei. Distinct helix propensities and membrane interactions of human and rat IAPP1–19 monomers in anionic lipid bilayers. J. Phys. Chem. B 2015, 119 (8): 3366-3376. 7. C. Guo, Y. Luo, R. Zhou and G. Wei. Triphenylalanine peptides self-assemble into nanospheres and nanorods that are different from the nanovesicles and nanotubes formed by diphenylalanine peptides. Nanoscale 2014, 6 (5): 2800-2811. 8. C. Guo, Y. Luo, R. Zhou and G. Wei. Probing the self-assembly mechanism of diphenylalanine-based peptide nanovesicles and nanotubes. ACS Nano 2012, 6 (5): 3907-3918. |